Association between sperm quality, oxidative stress, and seminal antioxidant activity. Access the effects of oxidative stress on female reproduction. Pdf oxidative stress as a concept in redox biology and medicine has been formulated in 1985. Reactive oxygen species ros are produced by living organisms as a result of normal cellular metabolism and environ mental factors, such as air. Biochemistry of oxidative stress physiopathology and. A free powerpoint ppt presentation displayed as a flash slide show on id. As free radical damage occurs, cells and tissues are damaged. Oxidative stress arises when the production of reactive oxygen species. Incr eased expression of no has been documented in dengue. Oxidative stress free download as powerpoint presentation. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Oxidative stress in plants dirk inze and marc van montagu universiteit gent, gent, belgium during the past few years, considerable progress has been made in understanding how plants protect themselves against oxidative stress. Role of oxidative stress in male infertility and antioxidant supplementation ashok agarwal, phd, hcld, is the director of research at the center for advanced research in human reproduction, infertility, and sexual function, and the director of the clinical andrology laboratory and reproductive tissue bank. Vladimir zivkovic1,dusica djordjevic2 and dragan djuric3.
H2o2 response to oxyr regulon superoxide response to soxrs regulon. Therefore, the effects on growth, oxidative stress, dna damage and apoptosis in t. Lecture outline free radical and antioxidants antioxidants. However, despite the biochemical plausibility, optimal dose, recommended timing of administration, and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following 4 weeks of oral gsh supplementation in healthy adults. Reac tive oxygen intermediate roi and reactive nitrogen intermediate rni are constantly produced under phy. The transparency document associated with this article. Oxidative stress hydrogen peroxide radical chemistry. Expression of cyp2e1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf. Assessment of oxidative stress assessment of oxidative stress cancer aging inflammation arteriosclerosis diabetes mucosa of the gut disease hepatic disease ischemic reperfusion cardiac disease. We conclude that alinduced genes can serve to protect against al toxicity, and also provide genetic evidence for a link between al stress and oxidative stress in plants.
Role of oxidative stress in male infertility and antioxidant. As oxidative stress is a unifying feature of almost all of the cardiovascular risk factors known to drive the atherosclerotic process, as well as a factor that is increased in response to neurohormonal abnormalities in heart failure and in cardiac ischaemia, a biomarker that reflects oxidative stress may be criticized for its lack of specificity. Reactive oxygen species ros are produced by living organisms as a result of normal cellular metabolism and environ. Ros caused oxidative damage inflicted on lipids, dna, and proteins. For example, oxidative stress induces apoptosis to prepare the birth canal for delivery. The current concept of oxidative stress should also include the pathways related to the nitrosative stress and, for their implication in cellular and extracel lular metabolic events, to the metabolic stress. It is also important to study the expression of oxidative stressrelated genes in toxicological studies. Induction of oxidative stress, apoptosis and dna damage by. Heart failure mat maurer, md irving assistant professor of medicine outline definitions and classifications epidemiology muscle and chamber function pathophysiology heart failure. Gif,psd, crd, pct, ppt, pdf, xls, doc, bmp, 123 or other lotus formats. Oxidative stress is thought to be linked to certain cardiovascular disease, since oxidation of ldl in the vascular endothelium is a precursor to plaque formation. Oxidative stress and alzheimers disease slideshare. However, despite the biochemical plausibility, optimal dose, recommended timing of administration, and appropriate choice of outcome measures, no significant changes were observed in oxidative stress biomarkers or erythrocyte glutathione concentrations following.
Scribd is the worlds largest social reading and publishing site. Pdf oxidative stress is a normal phenomenon in the body. Under normal conditions, cells are able to balance the production of oxidants and antioxidants. Effects of the reduced form of coenzyme q10 ubiquinol on semen parameters in men with idiopathic infertility. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience.
Heavy metals, co, ni, cu, zn and cd, produce oxidative damage. Numbers of evidences are supporting the involvement of oxidative and nitrosative stress in the pathophysiology. Physiopathology and clinical aspects, is that the academic and scientific background of the authorseditors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Oxidative stress is well known to be involved in the pathogenesis of lifestylerelated diseases, including atherosclerosis, hypertension, diabetes mellitus, ischemic diseases, and malignancies. Free radicals are oxygencontaining molecules with an uneven number of. Over time this disruption in the balance between free radicals and antioxidants can injure our tissues. Tables should be created with a word processor and saved in doc format. Oxidative stress occurs when there is imbalance in our cells due to either an increase in free radicals andor a decrease in antioxidants.
In addition, mtdna deletions increase in several tissues. Reactive oxygen species ros are produced by living organisms as a result of normal cellular metabolism and environmental factors, such as air pollutants or cigarette smoke. They may appear in their original format and may not be copy edited or formatted in the style guide of this journal. A further feature of oxidative stress that affects its clinical presentation is that it rarely. Sputum neutrophilic inflammation and biomarkers of oxidative stress in ebc can be considered good biomarkers of disease severity in ncfb patients, as confirmed by pulmonary function, disease duration, bacterial colonization, bsi score, and exacerbation rate. Journal of cellular neuroscience and oxidative stress author.
Journal of cellular neuroscience and oxidative stress. The sources of literature were pubmed and the cochrane data base. Do not submit figures in any of the following formats. Oxidative stress occurs when there is an imbalance in our cells due to either an increase in free radicals andor a decrease in antioxidants. Oxidative stress is a relatively new concept that can last 20 years or so developed in biomedical sciences. Oxidative stress can arise from overproduction of ros by metabolic reactions that use oxygen and shift the balance between oxidantantioxidant statuses in favor of the oxidants. Ppt what is oxidative stress powerpoint presentation free. To counteract oxidative stress, the body produces an armoury of antioxidants to defend itself. The effects of oxidative stress on female reproduction. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect.
Reactive oxygen species ros are small, highly reactive, oxygencontaining molecules that are naturally generated in small amounts during the bodys metabolic reactions and can react with. An altered redox balance mediates the hypersensitivity of. The alterations in intracellular ros content, oxidative dna damage, and metabolic profile were partially rescued by the addition of an antioxidant in the culture medium suggesting that the continuous oxidative stress that characterizes cs cells plays a causative role in the underlying pathophysiology. Oxidative stress is a condition of imbalances between oxidants and antioxidants 9.
Oxidative stress and exercise pdf myths, realities and physiological relevance. Oxidative stress occurs when there is imbalance in our cells due to either an increase in free radicals or a decrease in antioxidants. Ppt oxidative%20stress powerpoint presentation free to. A disturbance in the balance between reactive species or free radicals and antioxidants. Individual genetic information should also be taken into consideration. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Reac tive oxygen intermediate roi and reactive nitrogen intermediate rni are. Oxidative stress oxidative stress reactive oxygen species ros ros and oxidative stress antioxidant system oxidative damage oxidative stress and apoptosis oxidative. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from.
Hence, the outcome of oxidative stress on neuronal cells depends upon the ability of the cell to maintain. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and. Oxidative stress is imposed on cells as a result of one of three factors. Radak, z, et al, exercise, oxidative stress and hormesis, ageing res. Moreover, the implication of oxidative stress as a primary mechanism of al toxicity is still controversial. Jan 19, 2014 oxidative stress and alzheimers disease presented by mandeep kaur m. Mitochondrial dysfunction and oxidative stress are involved in metabolic disorders. P450 metabolism of xenobiotic compounds, stimulation of phagocytosis by. Thus, we chose several oxidative stressrelated genes to study the genotoxicity of koumine to t. Therefore, oxidative stress can also be viewed as an imbalance between the. Pdf oxidative stress, prooxidants, and antioxidants.
Its the job of antioxidants to neutralise or mop up free radicals that can harm our cells. Therefore, it is not surprising that there is a growing field of evidence demonstrating rutins therapeutic potential in many health conditions in which oxidative stress is an underlying cause. Al ions have a toxic effect on both plant and animal cells kochian, 1995. Pdf free radicals, reactive oxygen species, oxidative stresses and. Ppt what is oxidative stress powerpoint presentation.
If you continue browsing the site, you agree to the use of cookies on this website. Physiology of oxidative stress in humans and animals. However, oxidative stress is actually useful in some instances. Mitochondrial dysfunction and oxidative stress in metabolic disorders. In view of these reports, we aimed to study this relationship between smoking and oxidative stress in breast cancer patients from western region of nepal. Oxidative stress is a consequence, not a cause, of aluminum toxicity. Oxidative stress and antioxidant defense liposhell. Definitions an inability of the heart to pump blood at a sufficient rate to meet the metabolic demands of the body e. Role of oxidative stress, er stress and ubiquitin proteasome.
Oxidative stress is an imbalance between free radicals and antioxidants in your body. All forms of oxidative stress may not be equal in their effects on aging, hence the yeasts successful employment of speci. Ppt oxidative stress powerpoint presentation free to. Oxidative stress and human disease oxidative damage to dna, proteins, and other macromolecules has been implicated in the pathogenesis of a wide variety of diseases, most notably heart disease and cancer. Regulation of the oxidative stress response h2o2 response to oxyr regulon the oxyr regulon comprises nine of the proteins induced by h2o2. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Oxygen reactions in oxidative degradation and oxidative stress air contains 21% dioxygen, o2 animals, plants, and aerobic bacteria require dioxygen for efficient production of energy. Oxidative stress appears to be a common feature in individuals with asd chauhan and chauhan, 2006. Alcohol, oxidative stress, and free radical damage defeng wu, ph.
Effects of oral glutathione supplementation on systemic. It contributes significantly to the occurrence of pathophysiological conditions diseases such as diabetes, hypertension, preklampsie, atherosclerosis, acute. The role of antioxidant therapy in the treatment of male. Apr 22, 2014 oxidative stress appears to be a common feature in individuals with asd chauhan and chauhan, 2006. Role of oxidative stress in neurodegeneration oxidative stress os condition in the brain results from imbalance between ros and the bodys detoxification mechanism, which results in accumulation of ros and subsequent neuronal damage. Definition a disturbance in the balance between reactive oxygen species ros and antioxidants. Common sources of free radicals common sources of antioxidants. Oxidative stress also plays a role in the ischemic cascade due to oxygen reperfusion injury following hypoxia. This cascade includes both strokes and heart attacks.